Glycation is a slow chemical reaction with takes place between proteins and sugars in the skin as well as elsewhere in the body. It has been implicated in a variety of pathologies including cardiovascular and Alzheimer’s disease. It is now known that the skin is significantly affected by glycation reactions and it is a major contributor to the skin aging processes. This reaction is considered an important factor in the loss of desirable properties in collagen and elastin in the skin and is also detrimental to dermal fibroblasts cells. Recently the Director of Global Research for a very large personal care company indicated, “We now know that between 40 and 50% of skin aging is caused by glycation. It’s one of the worst skin agers; more than sun, more than environment.”
Dermal Renu® was developed to be a comprehensive skin care system and includes ingredients intended to reduce the incidence of the glycation reaction. Its ingredients include the well established anti-glycation peptide, carnosine and plantago extract with proven anti-glycation character. We have also added a unique phytoestrogen/anti-glycation ingredient, puerarian. Puerarian has been shown in independent studies as having very potent anti-glycation character. In fact, it was shown superior to the pharmaceutical anti-glycation benchmark, aminoguanidine. Puerarin is an isoflavone extract from the botanical pueraria mirifica and is found in both the Dermal Renu® AM and PM Treatments.
In addition to their antiglycation properties, ingredients in Dermal Renu® have been shown to stimulate the production of the critically important dermal cell structural element vimentin. This is important since it is the vimentin filaments that are most vulnerable to glycation. Thus, not only have ingredients in Dermal Renu® been shown to mitigate glycation, but they promote the production of vimentin in fibroblasts – a truly beneficial combination that is unusual in skin care products.
Dermal Renu ® is manufactured by Wellness Formulations, LLC. You can find this great product at It Makes Scents.
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